PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner
نویسندگان
چکیده
منابع مشابه
Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway.
OBJECTIVE Fluid shear stress (flow) modulates endothelial cell (EC) function via specific signal transduction events. Previously, we showed that flow-mediated tyrosine phosphorylation of p130 Crk-associated substrate (Cas) required calcium-dependent c-Src activation. Because flow increases reactive oxygen species (ROS) production in ECs and because H(2)O(2) increases tyrosine phosphorylation of...
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Recent genetic studies suggest that ephrins may function in a kinase-independent Eph receptor pathway. Here we report that expression of EphA8 in either NIH 3T3 or HEK293 cells enhanced cell adhesion to fibronectin via alpha(5)beta(1)- or beta(3) integrins. Interestingly, a kinase-inactive EphA8 mutant also markedly promoted cell attachment to fibronectin in these cell lines. Using a panel of E...
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ژورنال
عنوان ژورنال: Peptides
سال: 2019
ISSN: 0196-9781
DOI: 10.1016/j.peptides.2018.09.005